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The Neuroscientist
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*Epilepsy
*Seizures
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Article

Late-Onset Epileptogenesis and Seizure Genesis: Lessons From Models of Cerebral Ischemia

Jérôme Epsztein1, Yehezkel Ben-Ari1, Alfonso Represa1, and Valérie Crépel2*

1 INMED, INSERM, and Université de La Méditerranée, Marseille Cedex, France
2 Université de La Méditerranée, Marseille Cedex, France

* To whom correspondence should be addressed. E-mail: crepel{at}inmed.univ-mrs.fr.


  Abstract
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis. DOI: 10.1177/1073858407301681

First published on October 2, 2007, doi:10.1177/1073858407301681

The Neuroscientist 2008;14:78.

A more recent version of this article appeared on February 1, 2008
 This version was published on October 3, 2007
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