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Morphine: A Protective or Destructive Role in Neurons?

^* To whom correspondence should be addressed. E-mail: yanzhang{at}pku.edu.cn.

	Abstract

Morphine has received intensive research interest for a long time. However, until recently, the protective versus destructive roles of morphine in the neuronal system have not been studied. There is evidence suggesting that morphine induces apoptotic cell death in neuronal and glial cells, whereas controversial studies support a neuroprotective role for morphine. The exact mechanisms for both protective and destructive pathways are not clear and are still under investigation. Improved understanding of morphine neuroprotection and neurotoxicity will be helpful to control morphine side effects in medical applications and to identify new targets for potential therapies and prevention strategies to opioid addiction. NEUROSCIENTIST XX(X):xx–xx, XXXX. DOI: 10.1177/1073858408314434

First published on March 18, 2008, doi:10.1177/1073858408314434

The Neuroscientist 2008;14:561.

A more recent version of this article appeared on December 1, 2008


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