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Astrocyte Responses after Neonatal Ischemia: The Yin and the Yang
Sonia Villapol, PhD,
Antoinette Gelot, MD, PhD,
Sylvain Renolleau, MD, PhD,
and
Christiane Charriaut-Marlangue, PhD*
Université Pierre et Marie Curie, Paris, France
* To whom correspondence should be addressed. E-mail: Christiane.Marlangue{at}snv.jussieu.fr.
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Abstract |
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Neonatal encephalopathy is a major predictor of neurodevelopmental disability in term infants and occurs in 1 to 6 of every 1000 live term births. Despite improvements in perinatal practice during the past several decades, the incidence of cerebral palsy attributed to neonatal asphyxia remained essentially unchanged, primarily because management strategies were supportive and not targeted toward the processes of ongoing injury. Traditionally, experimental research in vivo focused on neurons, and more recently, oligodendrocytes whereas astrocytes have been more or less neglected. This review aims at dissecting possible protective as well as destructive roles of astrocytes in the immature ischemic brain to stimulate further research into this unexplored aspect of brain pathophysiology. NEUROSCIENTIST XX(X):xx–xx, XXXX. DOI: 10.1177/1073858408316003
First published on July 8, 2008, doi:10.1177/1073858408316003
The Neuroscientist 2008;14:339-a.
A more recent version of this article appeared on August 1, 2008
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